I designed an evidence-based management protocol for managing patients admitted to our teaching hospital with Covid19. The concept was minimalist: excluding irrational, untested, unproven therapies and focusing only on those which have been shown to work in large randomised trials. Here is a YouTube link to the powerpoint presentation:
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Covid
Covid and EBM- or lack of it…
The novel anti-Covid medicines look promising and appealing, but I’d urge caution in interpreting the study results…
Is Remdesivir a Rambaan remedy for Covid?
Last week, the district collector called a meeting. The meeting was attended, among other, by local MLAs, MPs, bureaucrats and doctors from the two medical colleges in the district. The second wave had peaked and more patients were seeking hospital admissions than the hospital could provide. ICU beds were at a premium and hospitals were …
Make hay while the sun shines: Unproven COVID drugs in India
India has the world’s second-largest COVID-19 outbreak. India desperately needs effective treatments. But the way the country’s drug regulator is handling potential therapies concerns many of us. The Drugs Controller General of India (DCGI) has approved several repurposed drugs for ‘restricted emergency use’ for treating the disease. On what basis were these drugs approved? Was …
Covid and Community Transmission
I see three challenges ahead vis-à-vis COVID-19 in India’s rural areas. First, many rural healthcare workers are exhausted and burned out. Second, lifestyle diseases like diabetes, high blood-pressure and heart problems have become more common in rural India in the last decade or so. Third, officials and healthcare workers have to contend with the spectre …
Covid: Evidence, Ethics and Economics
This afternoon I spoke on several issues that influence our thought processes when we see patients with Covid19- in the community, in the hospital OPD, wards or ICUs. How should we design our therapy? Should we allow ourselves to prescribe untested and unproven therapies because the atmosphere is filled with fear, desperation and panic? What …
Clinical Trials in Covid: Ethics and Practice
Fear. Panic. Desperation. Came Covid and most doctors began to prescribe anti-Covid drugs based not on scientific research, but based on anecdotes, media stories, newspapers, TV channels and promotion of drugs by the drug industry. The virus pushed the Evidence-based medicine to the back seat. Physicians were either reluctant to— or didn’t know how to— …
COVID-19: The need for evidence-based medicine
A number of old drugs approved for other diseases are being “repurposed” and tested for their safety and efficacy in COVID-19, in systematic clinical trials. They have emergency approval for use in COVID-19, but most are not yet proven for this use. Some drugs have received approval without adequate testing. Other drugs are being used …
Covid : Defining the Research Priorities?
Here is a YouTube link to the PowerPoint presentation.